Chinese scientists at Shandong University identify the FPR2 receptor for ceramide in adipocytes, advancing knowledge of metabolic disorders and offering new therapeutic possibilities.
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| Researchers at Shandong University have discovered FPR2 as a key receptor for ceramide in adipocytes, advancing the understanding of metabolic diseases and signaling pathways. Image Courtesy: SU |
Jinan, China — March 26, 2025:
A groundbreaking study led by Professor Sun Jinpeng at Shandong University has identified the critical membrane receptor for ceramide in adipocytes. Published in Science, the research titled "Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis" reveals that FPR2, a G protein-coupled receptor (GPCR), plays a key role in ceramide signaling within adipocytes. This discovery significantly enhances the understanding of how ceramide regulates adipocyte thermogenesis and uncovers the molecular basis of FPR2’s specificity for ceramide recognition.
Ceramide, a central molecule in the sphingomyelin metabolic pathway, has been implicated in metabolic disorders like diabetes, obesity, and atherosclerosis. The research identifies FPR2 as a vital receptor for ceramide, offering new insights into the molecular mechanisms behind these diseases. Using high-throughput screening and animal models, the team demonstrated how ceramide influences metabolic signaling and cellular responses, presenting potential avenues for targeted therapies.
Furthermore, the study delves into the unclear mechanisms of interorgan ceramide transport and its regulation of target cells, providing vital clues for developing treatments for metabolic disorders. The rapid regulatory effects observed—such as ceramide’s impact on glucose transport within minutes—suggest the presence of membrane receptor-mediated mechanisms that could enable fast cellular responses, which are crucial for future therapeutic approaches.